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Article

HDAC3 single-nucleotide polymorphism rs2530223 is associated with increased susceptibility and severity of primary immune thrombocytopenia.

International journal of laboratory hematology - 1 Oct 2022

Liu Yan, Wang Yin, Zhang Cheng, Feng Qi, Hou Ming, Peng Jun, Hu Xiang, Wang Shuwen

Abstract excerpt

INTRODUCTION: Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by a low platelet count and increased risk of bleeding. We previously reported that low-dose chidamide, a histone deacetylase (HDAC) inhibitor, restores immune tolerance in patients with ITP. This study aimed to evaluate the association of a single-nucleotide polymorphism (SNP) rs2530223 in the HDAC3 gene with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35484920
DOI: 10.1111/ijlh.13857

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