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Article

Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease.

Autoimmunity - 1 Aug 2016

Sarumaru Mika, Watanabe Mikio, Inoue Naoya, Hisamoto Yuko, Morita Emi, Arakawa Yuya, Hidaka Yoh, Iwatani Yoshinori

Abstract excerpt

Sirtuin1 (SIRT1) is a Class 3 nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) that is thought to be implicated in the protection against autoimmune diseases. However, an association between SIRT1 and autoimmune thyroid disease (AITD) has not been reported. In this study, we selected four single nucleotide polymorphisms (SNPs) in the SIRT1 gene, rs12049646 T/C (termed SNP1), rs12778366 T/C...

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Source

Identifiers

PMID: 27245255
DOI: 10.3109/08916934.2015.1134506

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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