Article
STAT1 single nucleotide polymorphisms and susceptibility to immune thrombocytopenia.
Autoimmunity - 1 Jan 2015
Chen Zhenping, Guo Zhenxing, Ma Jingyao, Liu Fuhong, Gao Chao, Liu Shuguang, Wang Ami, Wu Runhui
Abstract excerpt
Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder. One of the key mediators of IFN-γ signaling is the signal transducer and activator of transcription 1 protein (STAT1). We evaluated the relationship between STAT1 gene single nucleotide polymorphisms (SNPs) and the associated risk of ITP in a prospective case-control study. A total of 548 children were recruited: 328 children with...
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