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Article

SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus.

Molecular biology reports - 1 Jul 2014

Consiglio Camila Rosat, Juliana da Silveira Schauren, Monticielo Odirlei André, Xavier Ricardo Machado, Brenol João Carlos Tavares, Chies José Artur Bogo

Abstract excerpt

Silent mating type Information Regulator 2 homolog 1 (SIRT1) is a deacetylase protein that participates in several physiological processes with importance in transcriptional silencing, apoptosis, immune system regulation and inflammation. Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease in which upregulated expression of SIRT1 on CD4+ T lymphocytes of active patients has been reported....

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Source

Identifiers

PMID: 24570024
DOI: 10.1007/s11033-014-3294-3

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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