Article
The role of a monoclonal antibody 11C8B1 as a diagnostic marker of IDH2-mutated sinonasal undifferentiated carcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2019
Dogan Snjezana, Frosina Denise, Fayad Miriam, de Oliveira Thais Basili, Alemar Barbara, Rosenblum Marc, Tang Laura H, Hameed Meera, Xu Bin, Ghossein Ronald A, Chute Deborah J, Weigelt Britta, Jungbluth Achim A
Abstract excerpt
IDH2 R172 mutations occur in >80% sinonasal undifferentiated carcinomas ("SNUC") and ~80% of these are R172S and R172T variants. We examined the utility of the monoclonal antibody 11C8B1 to IDH2 R172S in IDH2 R172-mutated tumors to establish an immunohistochemistry protocol as a surrogate method for IDH2 R172S mutation detection. Eighty-eight formalin-fixed paraffin-embedded tumors including 42 sinonasal tumors...
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