Article
Immunohistochemical Detection and Molecular Characterization of IDH-mutant Sinonasal Undifferentiated Carcinomas.
The American journal of surgical pathology - 1 Aug 2018
Mito Jeffrey K, Bishop Justin A, Sadow Peter M, Stelow Edward B, Faquin William C, Mills Stacey E, Krane Jeffrey F, French Christopher A, Fletcher Christopher D M, Hornick Jason L, Sholl Lynette M, Jo Vickie Y
Abstract excerpt
Recent studies have identified recurrent isocitrate dehydrogenase 2 (IDH2) mutations in a subset of sinonasal undifferentiated carcinomas (SNUCs); however, the true frequency of IDH mutations in SNUC is unknown. We evaluated the utility of mutation-specific IDH1/2 immunohistochemistry (IHC) in a large multi-institutional cohort of SNUC and morphologic mimics. IHC using a multispecific antibody for IDH1/2...
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