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Article

Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2017

Jo Vickie Y, Chau Nicole G, Hornick Jason L, Krane Jeffrey F, Sholl Lynette M

Abstract excerpt

Sinonasal undifferentiated carcinoma is a rare and aggressive malignancy. Sinonasal undifferentiated carcinoma has long been considered a diagnosis of exclusion; to date, the molecular pathogenetic basis for sinonasal undifferentiated carcinoma is unknown. To identify potential oncogenic drivers in sinonasal undifferentiated carcinoma, targeted next-generation sequencing of 300 cancer-related genes was performed...

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Source

Identifiers

PMID: 28084339
DOI: 10.1038/modpathol.2016.239

Genes

IDH2
IDH1
NOTCH1
SMARCA4
TET2

Variants

Provenance

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