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Article

Molecular epidemiology of IDH2 hotspot mutations in cancer and immunohistochemical detection of R172K, R172G, and R172M variants.

Human pathology - 1 Dec 2020

Dogan Snjezana, Frosina Denise, Geronimo Jerica A, Hernandez Enmily, Mohanty Abhinita, Bale Tejus, Hechtman Jaclyn F, Arcila Maria E, Hameed Meera R, Jungbluth Achim A

Abstract excerpt

IDH1/2 hotspot mutations occur in glioma, cholangiocarcinoma, chondrosarcoma, sinonasal carcinoma, and T-cell lymphoma and have diagnostic, prognostic, and/or therapeutic value. Availability of immunohistochemistry (IHC) protocols for specific IDH2 mutation detection is limited. A targeted exome sequencing assay MSK-IMPACT cohort comprising >38,000 cancer cases was explored for the presence of IDH1/2 mutations in...

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Identifiers

PMID: 33017591
DOI: 10.1016/j.humpath.2020.09.013
PMCID: PMC7721993

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