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Article

Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.

The Journal of pathology - 1 Aug 2017

Dogan Snjezana, Chute Deborah J, Xu Bin, Ptashkin Ryan N, Chandramohan Raghu, Casanova-Murphy Jacklyn, Nafa Khedoudja, Bishop Justin A, Chiosea Simion I, Stelow Edward B, Ganly Ian, Pfister David G, Katabi Nora, Ghossein Ronald A, Berger Michael F

Abstract excerpt

Sinonasal undifferentiated carcinoma (SNUC) is a high-grade malignancy with limited treatment options and poor outcome. A morphological spectrum of 47 sinonasal tumours including 17 (36.2%) SNUCs was analysed at genomic level. Thirty carcinomas (cohort 1) were subjected to a hybridization exon-capture next-generation sequencing assay (MSK-IMPACTTM ) to interrogate somatic variants in 279 or 410 cancer-related...

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Source

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Identifiers

PMID: 28493366
DOI: 10.1002/path.4915
PMCID: PMC5639875

Genes

IDH2
AKT1
IDH1
KIT
MYC
SETD2
SMARCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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