Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart Disease

31 Mar 2012

Abstract excerpt

Chemical biology promises discovery of new and unexpected mechanistic pathways, protein functions and disease targets. Here, we probed the mechanism-of-action and protein targets of 3,5-disubstituted isoxazoles (Isx), cardiomyogenic small molecules that target Notch-activated epicardium-derived cells (NECs) in vivo and promote functional recovery after myocardial infarction (MI). Mechanistic studies in NECs led...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22462679
DOI: 10.1021/cb300001m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart DiseasePMID 22462679Read ↗

A phenotypic screen identified KEAP1-kelch domain blockade as a mechanism to restore cardiac function in the setting of chronic severe hemodynamic stressSemantic proximity Read ↗

Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.Semantic proximity Read ↗

Proton Pump Inhibitors and Cardiac Safety: Emerging Evidence Linking Cardiovascular Disease, Arrhythmias, and Mechanistic PathwaysSemantic proximity Read ↗

Deconvoluting Kinase Inhibitor Induced CardiotoxicitySemantic proximity Read ↗

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.Semantic proximity Read ↗

Molecular basis of proton-sensing by G protein-coupled receptorsSemantic proximity Read ↗

Proton-gating of opioid receptors and isoform functionalitySemantic proximity Read ↗

Humanin analogue promotes metabolic reprogramming to protect the ischemic heartSemantic proximity Read ↗

Artificial Intelligence Uncovers Evolutionarily Conserved Intracellular Allosteric Modulators of GPCR-Gα InterfaceSemantic proximity Read ↗

A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.Semantic proximity Read ↗

The Roles of Proton-Sensing G-Protein-Coupled Receptors in Inflammation and CancerSemantic proximity Read ↗

RNA‐Seq analysis of knocking out the neuroprotective proton‐sensitive GPR68 on basal and acute ischemia‐induced transcriptome changes and signaling in mouse brainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.