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Article

A cell-based phenotypic assay to identify cardioprotective agents.

Circulation research - 30 Mar 2012

Guo Stephanie, Olm-Shipman Adam, Walters Andrew, Urciuoli William R, Devito Stefanie, Nadtochiy Sergiy M, Wojtovich Andrew P, Brookes Paul S

Abstract excerpt

RATIONALE: Tissue ischemia/reperfusion (IR) injury underlies several leading causes of death such as heart-attack and stroke. The lack of clinical therapies for IR injury may be partly due to the difficulty of adapting IR injury models to high-throughput screening (HTS). OBJECTIVE: To develop a model of IR injury that is both physiologically relevant and amenable to HTS. METHODS AND RESULTS: A microplate-based...

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Identifiers

PMID: 22394516
DOI: 10.1161/CIRCRESAHA.111.263715
PMCID: PMC3329894

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