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Article

A genome-wide analysis of the molecular alterations occurring in the adenomatous and carcinomatous components of the same tumor based on the adenoma-carcinoma sequence.

Pathology international - 1 Sept 2021

Sugai Tamotsu, Osakabe Mitsumasa, Habano Wataru, Tanaka Yoshihito, Eizuka Makoto, Sugimoto Ryo, Yanagawa Naoki, Matsumoto Takayuki, Suzuki Hiromu

Abstract excerpt

Identification of molecular alterations occurring in the adenomatous and carcinomatous components within the same tumor would greatly enhance understanding of the neoplastic progression of colorectal cancer. We examined somatic copy number alterations (SCNAs) and mRNA expression at the corresponding loci involved in the adenoma-carcinoma sequence in the isolated adenomatous and cancer glands of the same tumor in...

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Identifiers

PMID: 34263942
DOI: 10.1111/pin.13129
PMCID: PMC8518074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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