Article
Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.
Genes, chromosomes & cancer - 1 May 2013
Loo Lenora W M, Tiirikainen Maarit, Cheng Iona, Lum-Jones Annette, Seifried Ann, Church James M, Gryfe Robert, Weisenberger Daniel J, Lindor Noralane M, Gallinger Steven, Haile Robert W, Duggan David J, Thibodeau Stephen N, Casey Graham, Le Marchand Loïc
Abstract excerpt
Microsatellite stable (MSS), CpG island methylator phenotype (CIMP)-negative colorectal tumors, the most prevalent molecular subtype of colorectal cancer, are associated with extensive copy number alteration (CNA) events and aneuploidy. We report on the identification of characteristic recurrent CNA (with frequency >25%) events and associated gene expression profiles for a total of 40 paired tumor and adjacent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.