Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer

29 Apr 2022

Abstract excerpt

In colorectal cancer, somatic mutations have played an important role as prognostic and predictive biomarkers, with some also functioning as therapeutic targets. Another genetic aberration that has shown significance in colorectal cancer is copy number alterations (CNAs). CNAs occur when a change to the DNA structure propagates gain/amplification or loss/deletion in sections of DNA, which can often lead to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Genomic variations and chromosomal abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35565354
DOI: 10.3390/cancers14092223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal CancerPMID 35565354Read ↗

The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcomeSemantic proximity Read ↗

Copy Number Alteration Signatures As Biomarkers in Cancer: A ReviewSemantic proximity Read ↗

Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkersSemantic proximity Read ↗

Copy number variations primed lncRNAs deregulation contribute to poor prognosis in colorectal cancerSemantic proximity Read ↗

Predisposition to colorectal cancer: exploiting copy number variation to identify novel predisposing genes and mechanisms.Semantic proximity Read ↗

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancersSemantic proximity Read ↗

Clinical applications of next-generation sequencing in colorectal cancers.Semantic proximity Read ↗

GAEC1 mutations and copy number aberration is associated with biological aggressiveness of colorectal cancer.Semantic proximity Read ↗

Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component.Semantic proximity Read ↗

Reduced rate of copy number aberrations in mucinous colorectal carcinoma.Semantic proximity Read ↗

Genomic Landscape of Copy Number Aberrations Enables the Identification of Oncogenic Drivers in Hepatocellular CarcinomaSemantic proximity Read ↗

Single-cell copy number alteration signature analysis reveals masked patterns and potential biomarkers for cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.