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Article

Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays.

Journal of gastroenterology - 1 Nov 2017

Eizuka Makoto, Sugai Tamotsu, Habano Wataru, Uesugi Noriyuki, Takahashi Yayoi, Kawasaki Keisuke, Yamamoto Eiichiro, Suzuki Hiromu, Matsumoto Takayuki

Abstract excerpt

BACKGROUND: We examined colorectal adenomas and intramucosal adenocarcinomas (IMAs) to develop a genome-wide overview of copy number alterations (CNAs) during colorectal tumorigenesis. METHODS: We analysed CNAs using a high-resolution SNP array of isolated tumour glands obtained from 55 colorectal adenomas (35 low-grade adenomas and 20 high-grade adenomas) and 30 IMAs. Next, we examined whether frequent CNAs...

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Identifiers

PMID: 28197804
DOI: 10.1007/s00535-017-1317-2
PMCID: PMC5666076

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