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Article

A genome-wide study of the relationship between chromosomal abnormalities and gene expression in colorectal tumors.

Genes, chromosomes & cancer - 1 Apr 2021

Sugai Tamotsu, Osakabe Mitsumasa, Sugimoto Ryo, Eizuka Makoto, Tanaka Yoshihito, Yanagawa Naoki, Otsuka Koki, Sasaki Akira, Matsumoto Takayuki, Suzuki Hiromu

Abstract excerpt

The role of somatic copy number alterations (SCNAs) that occur in colorectal tumors is poorly understood. SCNAs are correlated with corresponding gene expression changes that may contribute to neoplastic progression. Thus, we examined SCNAs and the expression of messenger RNAs (mRNAs) located at corresponding loci in colorectal neoplasia, a progression model of human neoplasm. We used 42 colorectal neoplastic...

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Identifiers

PMID: 33258187
DOI: 10.1002/gcc.22924
PMCID: PMC7898915

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