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Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer

4 Aug 2015

Abstract excerpt

Colorectal cancer (CRC) is characterized by specific patterns of copy number alterations (CNAs), which helped with the identification of driver oncogenes and tumor suppressor genes (TSGs). More recently, the usage of single nucleotide polymorphism arrays provided information of copy number neutral loss of heterozygosity, thus suggesting the occurrence of somatic uniparental disomy (UPD) and uniparental polysomy...

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PMID: 26243311
DOI: 10.1093/carcin/bgv115

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