Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death.

EMBO reports - 1 Oct 2007

Cribbs J Thomas, Strack Stefan

Abstract excerpt

Opposing mitochondrial fission and fusion reactions determine the shape and interconnectivity of mitochondria. Dynamin-related protein 1 (Drp1) is an ancient mechanoenzyme that uses GTP hydrolysis to power the constriction and division of mitochondria. Although Drp1-mediated mitochondrial fragmentation is recognized as an early event in the apoptotic programme, acute regulation of Drp1 activity is poorly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to GTP Phosphohydrolases

Share to Mitochondrial Proteins

Share to Serine

Share to Staurosporine

Source

Open in PubMed Open full text

Identifiers

PMID: 17721437
DOI: 10.1038/sj.embor.7401062
PMCID: PMC2002551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death.PMID 17721437Read ↗

Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.Semantic proximity Read ↗

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.Semantic proximity Read ↗

Serine 39 in the GTP-binding domain of Drp1 is involved in shaping mitochondrial morphology.Semantic proximity Read ↗

PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics.Semantic proximity Read ↗

[Mitochondrial morphology and dynamics: actors, mechanisms and functions].Semantic proximity Read ↗

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology.Semantic proximity Read ↗

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.Semantic proximity Read ↗

Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation.Semantic proximity Read ↗

Mitochondrial fission in apoptosis, neurodegeneration and aging.Semantic proximity Read ↗

Dynamin-Related Protein 1 at the Crossroads of CancerSemantic proximity Read ↗

Emerging functions of mammalian mitochondrial fusion and fission.Semantic proximity Read ↗

Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.