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Article

Serine 39 in the GTP-binding domain of Drp1 is involved in shaping mitochondrial morphology.

FEBS open bio - 1 Jul 2024

Ghani Marvi, Szabó Bernadett, Alkhatibe Mahmoud, Amsalu Hailemariam, Zohar Peleg, Janka Eszter Anna, Mótyán János András, Tar Krisztina

Abstract excerpt

Continuous fusion and fission are critical for mitochondrial health. In this study, we further characterize the role played by dynamin-related protein 1 (Drp1) in mitochondrial fission. We show that a single amino acid change in Drp1 at position 39 from serine to alanine (S39A) within the GTP-binding (GTPase) domain results in a fused mitochondrial network in human SH-SY5Y neuroblastoma cells. Interestingly, the...

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Identifiers

PMID: 38760979
DOI: 10.1002/2211-5463.13820
PMCID: PMC11216946

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