Article

Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission

2023-05-04

Abstract excerpt

Mitochondrial Fission Protein 1 (Fis1) and Dynamin Related Protein 1 (Drp1) are the only two proteins evolutionarily conserved for mitochondrial fission, and directly interact in S. cerevisiae to facilitate membrane scission. However, it remains unclear if a direct interaction is conserved in higher eukaryotes as other Drp1 recruiters, not present in yeast, are known. Using NMR, differential scanning fluorimetry,...

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Literature Corpus work: 74671ba5-ebdd-58cf-b316-998b00a20713
DOI: 10.1101/2023.05.03.539292

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