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Article

Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier.

The EMBO journal - 1 Jul 2024

Senoo Nanami, Chinthapalli Dinesh K, Baile Matthew G, Golla Vinaya K, Saha Bodhisattwa, Oluwole Abraham O, Ogunbona Oluwaseun B, Saba James A, Munteanu Teona, Valdez Yllka, Whited Kevin, Sheridan Macie S, Chorev Dror, Alder Nathan N, May Eric R, Robinson Carol V, Claypool Steven M

Abstract excerpt

Lipid-protein interactions play a multitude of essential roles in membrane homeostasis. Mitochondrial membranes have a unique lipid-protein environment that ensures bioenergetic efficiency. Cardiolipin (CL), the signature mitochondrial lipid, plays multiple roles in promoting oxidative phosphorylation (OXPHOS). In the inner mitochondrial membrane, the ADP/ATP carrier (AAC in yeast; adenine nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38839991
DOI: 10.1038/s44318-024-00132-2
PMCID: PMC11251061

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