Article

Structural Basis of Mitochondrial Receptor Binding and GTP-Driven Conformational Constriction by Dynamin-Related Protein 1

2017-08-04

Abstract excerpt

Mitochondrial inheritance, genome maintenance, and metabolic adaptation all depend on organelle fission by D ynamin- R elated P rotein 1 (DRP1) and its mitochondrial receptors. DRP1 receptors include the paralogs M itochondrial D ynamics 49 and 51 (MID49/MID51) and M itochondrial F ission F actor (MFF), but the mechanisms by which these proteins recruit DRP1 and regulate its activities are unknown. Here we...

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Literature Corpus work: 853580ae-d6d4-5cd0-9bf9-8792dae4e0a0
DOI: 10.1101/172809

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