Article
Sufu negatively regulates both initiations of centrosome duplication and DNA replication.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2021
Zhuang Tenghan, Zhang Boyan, Song Yihong, Huang Fan, Chi Wangfei, Xin Guangwei, Zhang Ziyu, Cheng Steven Y, Jiang Qing, Zhang Chuanmao
Abstract excerpt
Centrosome duplication and DNA replication are two pivotal events that higher eukaryotic cells use to initiate proliferation. While DNA replication is initiated through origin licensing, centrosome duplication starts with cartwheel assembly and is partly controlled by CP110. However, the upstream coordinator for both events has been, until now, a mystery. Here, we report that suppressor of fused protein (Sufu), a...
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