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Article

Global Proteotoxicity Caused by Human β2 Microglobulin Variants Impairs the Unfolded Protein Response in C. elegans.

International journal of molecular sciences - 4 Oct 2021

Good Sarah C, Dewison Katherine M, Radford Sheena E, van Oosten-Hawle Patricija

Abstract excerpt

Aggregation of β2 microglobulin (β2m) into amyloid fibrils is associated with systemic amyloidosis, caused by the deposition of amyloid fibrils containing the wild-type protein and its truncated variant, ΔN6 β2m, in haemo-dialysed patients. A second form of familial systemic amyloidosis caused by the β2m variant, D76N, results in amyloid deposits in the viscera, without renal dysfunction. Although the folding and...

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Identifiers

PMID: 34639093
DOI: 10.3390/ijms221910752
PMCID: PMC8509642

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