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Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice.

Translational psychiatry - 12 Jul 2021

Garza-Lombó Carla, Thang Morrent, Greve Hendrik J, Mumaw Christen L, Messenger Evan J, Ahmed Chandrama, Quinn Emily, Sullivan Kimberly, Block Michelle L

Abstract excerpt

Gulf War Illness (GWI) is a chronic, multi-symptom peripheral and CNS condition with persistent microglial dysregulation, but the mechanisms driving the continuous neuroimmune pathology are poorly understood. The alarmin HMGB1 is an autocrine and paracrine pro-inflammatory signal, but the role of circulating HMGB1 in persistent neuroinflammation and GWI remains largely unknown. Using the LPS model of the...

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Identifiers

PMID: 34253711
DOI: 10.1038/s41398-021-01517-1
PMCID: PMC8275600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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