Article
Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis.
Scientific reports - 17 Jul 2017
Rivera Natalia V, Hagemann-Jensen Michael, Ferreira Manuel A R, Kullberg Susanna, Eklund Anders, Martin Nicholas G, Padyukov Leonid, Grunewald Johan
Abstract excerpt
The involvement of the immune system, particularly the role of T-cells, in sarcoidosis is unclear. The existence of higher CD4+ T-cells and increased CD4/CD8 ratio may indicate a pathogenic role of T-cells in the disease. In this study, we quantified the contribution of T-cells associated variants and of CD4/CD8 ratio in sarcoidosis phenotypes, Löfgren's syndrome (LS) and non- Löfgren's syndrome (non-LS). We...
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