Article
Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2015
Bellini Angela, Bernard Virginie, Leroy Quentin, Rio Frio Thomas, Pierron Gaelle, Combaret Valérie, Lapouble Eve, Clement Nathalie, Rubie Herve, Thebaud Estelle, Chastagner Pascal, Defachelles Anne Sophie, Bergeron Christophe, Buchbinder Nimrod, Taque Sophie, Auvrignon Anne, Valteau-Couanet Dominique, Michon Jean, Janoueix-Lerosey Isabelle, Delattre Olivier, Schleiermacher Gudrun
Abstract excerpt
PURPOSE: In neuroblastoma, activating ALK receptor tyrosine kinase point mutations play a major role in oncogenesis. We explored the potential occurrence of ALK mutations at a subclonal level using targeted deep sequencing. EXPERIMENTAL DESIGN: In a clinically representative series of 276 diagnostic neuroblastoma samples, exons 23 and 25 of the ALK gene, containing the F1174 and R1275 mutation hotspots,...
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