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Article

Clinical Impact of Tumor Mutational Burden in Neuroblastoma

9 Aug 2018

Abstract excerpt

BACKGROUND: Neuroblastoma is the most common pediatric extracranial solid tumor. Within conventional risk groups, there is considerable heterogeneity in outcomes, indicating the need for improved risk stratification. METHODS: In this study we analyzed the somatic mutational burden of 515 primary, untreated neuroblastoma tumors from three independent cohorts. Mutations in coding regions were determined by...

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PMID: 30307503
DOI: 10.1093/jnci/djy157

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