Article
Frequency and Clinical Significance of Clonal and Subclonal Driver Mutations in High-Risk Neuroblastoma at Diagnosis: A Children's Oncology Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2025
Berko Esther R, Naranjo Arlene, Daniels Alexander A, McNulty Samantha N, Krytska Kateryna, Druley Todd, Zelley Kirstin, Koneru Balakrishna, Chen Lulu, Polkosnik Grace, Irwin Meredith S, Bagatell Rochelle, Maris John M, Reynolds C Patrick, DuBois Steven G, Park Julie R, Mossé Yael P
Abstract excerpt
PURPOSE: Relapsed high-risk neuroblastomas (NBLs) are enriched for targetable mutations in ALK and RAS-MAPK pathways, yet the prognostic effect of these aberrations and relevance of subclonal mutations at diagnosis remain undefined. We describe the spectrum and clinical significance of clonal and subclonal pathogenic alterations in high-risk NBL. METHODS: We developed a focused high-risk NBL sequencing panel...
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