Article
Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2010
De Brouwer Sara, De Preter Katleen, Kumps Candy, Zabrocki Piotr, Porcu Michaël, Westerhout Ellen M, Lakeman Arjan, Vandesompele Jo, Hoebeeck Jasmien, Van Maerken Tom, De Paepe Anne, Laureys Geneviève, Schulte Johannes H, Schramm Alexander, Van Den Broecke Caroline, Vermeulen Joëlle, Van Roy Nadine, Beiske Klaus, Renard Marleen, Noguera Rosa, Delattre Olivier, Janoueix-Lerosey Isabelle, Kogner Per, Martinsson Tommy, Nakagawara Akira, Ohira Miki, Caron Huib, Eggert Angelika, Cools Jan, Versteeg Rogier, Speleman Frank
Abstract excerpt
PURPOSE: Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and clinical parameters, and studied the prognostic significance of ALK copy number and expression. EXPERIMENTAL DESIGN: The frequency and type of ALK mutations, copy...
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