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Article

Exosomal IDH1 increases the resistance of colorectal cancer cells to 5-Fluorouracil

1 Jan 2021

Abstract excerpt

Chemoresistance challenges the clinical treatment of colorectal cancer and requires an urgent solution. Isocitrate dehydrogenase 1 (IDH1) is a key enzyme involved in glucose metabolism that mediates the malignant transformation of tumors. However, the mechanisms by which IDH1 is involved in colorectal cancer cell proliferation and drug resistance induction remain unclear. In this study, we found that IDH1 was...

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PMID: 34234856
DOI: 10.7150/jca.58846

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