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Article

TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity.

Oncogene - 1 Jan 2023

Yang Hao, Zhao Xiaoping, Liu Jianjun, Jin Mingming, Liu Xiyu, Yan Jun, Yao Xufeng, Mao Xinyi, Li Nan, Liang Beibei, Xie Wei, Zhang Kunchi, Zhao Jian, Liu Liu, Huang Gang

Abstract excerpt

The heterogeneity and drug resistance of colorectal cancer (CRC) often lead to treatment failure. Isocitrate dehydrogenase 1 (IDH1), a rate-limiting enzyme in the tricarboxylic acid cycle, regulates the intracellular redox environment and mediates tumor cell resistance to chemotherapeutic drugs. The aim of this study was to elucidate the mechanism underlying the involvement of IDH1 acetylation in the development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36352097
DOI: 10.1038/s41388-022-02528-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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