Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancer

24 Mar 2025

Abstract excerpt

Chemotherapy remains the primary treatment for unresectable or advanced postoperative colorectal cancers. However, its effectiveness is compromised by chemoresistance, which adversely affects patient outcomes. Dysregulated macroautophagy/autophagy is a proposed mechanism behind this resistance, with ubiquitination playing a key regulatory role. In this study, we identify the transcription factor HMBOX1 (homeobox...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40126194
DOI: 10.1080/15548627.2025.2477443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancerPMID 40126194Read ↗

NSUN5 Mediates Resistance to Doxorubicin via Up-regulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal CancerSemantic proximity Read ↗

The role of GLI1 for 5-Fu resistance in colorectal cancerSemantic proximity Read ↗

FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10Semantic proximity Read ↗

MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathwaySemantic proximity Read ↗

Understanding microRNA-Mediated Chemoresistance in Colorectal Cancer TreatmentSemantic proximity Read ↗

ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yieldSemantic proximity Read ↗

LncRNAs as Regulators of Autophagy and Drug Resistance in Colorectal CancerSemantic proximity Read ↗

Exosomal IDH1 increases the resistance of colorectal cancer cells to 5-FluorouracilSemantic proximity Read ↗

CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancerSemantic proximity Read ↗

Loss of <i>UBP1</i> drives oxaliplatin resistance through a targetable dependency on translation initiationSemantic proximity Read ↗

UBE2S promotes 5-fluorouracil resistance in colorectal cancer by activating non-canonical NF-κB/TYMS/TK1 signalingSemantic proximity Read ↗

LncRNA FEZF1-AS1 Promotes Multi-Drug Resistance of Gastric Cancer Cells via Upregulating ATG5Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.