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Article

Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis.

PloS one - 1 Jan 2021

Liu Xun, Yamaguchi Kiyoshi, Takane Kiyoko, Zhu Chi, Hirata Makoto, Hikiba Yoko, Maeda Shin, Furukawa Yoichi, Ikenoue Tsuneo

Abstract excerpt

Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and their key effector 2-hydroxyglutarate (2-HG) have been reported to promote oncogenesis in various human cancers. To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we established mouse embryonic fibroblasts (MEF) cells and human colorectal cancer cells stably expressing cancer-associated IDH1R132C or IDH2R172S, and analyzed the change in...

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Identifiers

PMID: 34516556
DOI: 10.1371/journal.pone.0257090
PMCID: PMC8437293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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