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Article

CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem.

The Journal of comparative neurology - 1 Aug 2021

Milinkeviciute Giedre, Chokr Sima M, Castro Emily M, Cramer Karina S

Abstract excerpt

The precise and specialized circuitry in the auditory brainstem develops through adaptations of cellular and molecular signaling. We previously showed that elimination of microglia during development impairs synaptic pruning that leads to maturation of the calyx of Held, a large encapsulating synapse that terminates on neurons of the medial nucleus of the trapezoid body (MNTB). Microglia depletion also led to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Evoked Potentials, Auditory, Brain Stem

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Identifiers

PMID: 33797066
DOI: 10.1002/cne.25150
PMCID: PMC8174095

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