Article
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex.
Neuron - 21 Sept 2016
He Miao, Tucciarone Jason, Lee SooHyun, Nigro Maximiliano José, Kim Yongsoo, Levine Jesse Maurica, Kelly Sean Michael, Krugikov Illya, Wu Priscilla, Chen Yang, Gong Ling, Hou Yongjie, Osten Pavel, Rudy Bernardo, Huang Z Josh
Abstract excerpt
Systematic genetic access to GABAergic cell types will facilitate studying the function and development of inhibitory circuitry. However, single gene-driven recombinase lines mark relatively broad and heterogeneous cell populations. Although intersectional approaches improve precision, it remains unclear whether they can capture cell types defined by multiple features. Here we demonstrate that combinatorial...
Topics
- Animals
- Cerebral Cortex
- GABAergic Neurons
- Genetic Vectors
- Mice
- Mutation
- Neural Stem Cells
- Recombinases
- Viruses