Article
Reversing behavioural abnormalities in mice exposed to maternal inflammation.
Nature - 28 Sept 2017
Shin Yim Yeong, Park Ashley, Berrios Janet, Lafourcade Mathieu, Pascual Leila M, Soares Natalie, Yeon Kim Joo, Kim Sangdoo, Kim Hyunju, Waisman Ari, Littman Dan R, Wickersham Ian R, Harnett Mark T, Huh Jun R, Choi Gloria B
Abstract excerpt
Viral infection during pregnancy is correlated with increased frequency of neurodevelopmental disorders, and this is studied in mice prenatally subjected to maternal immune activation (MIA). We previously showed that maternal T helper 17 cells promote the development of cortical and behavioural abnormalities in MIA-affected offspring. Here we show that cortical abnormalities are preferentially localized to a...
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