Article
Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium.
PloS one - 1 Jan 2015
Bis Joshua C, Sitlani Colleen, Irvin Ryan, Avery Christy L, Smith Albert Vernon, Sun Fangui, Evans Daniel S, Musani Solomon K, Li Xiaohui, Trompet Stella, Krijthe Bouwe P, Harris Tamara B, Quibrera P Miguel, Brody Jennifer A, Demissie Serkalem, Davis Barry R, Wiggins Kerri L, Tranah Gregory J, Lange Leslie A, Sotoodehnia Nona, Stott David J, Franco Oscar H, Launer Lenore J, Stürmer Til, Taylor Kent D, Cupples L Adrienne, Eckfeldt John H, Smith Nicholas L, Liu Yongmei, Wilson James G, Heckbert Susan R, Buckley Brendan M, Ikram M Arfan, Boerwinkle Eric, Chen Yii-Der Ida, de Craen Anton J M, Uitterlinden Andre G, Rotter Jerome I, Ford Ian, Hofman Albert, Sattar Naveed, Slagboom P Eline, Westendorp Rudi G J, Gudnason Vilmundur, Vasan Ramachandran S, Lumley Thomas, Cummings Steven R, Taylor Herman A, Post Wendy, Jukema J Wouter, Stricker Bruno H, Whitsel Eric A, Psaty Bruce M, Arnett Donna
Abstract excerpt
BACKGROUND: Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke. In the US, over 65 million people have high blood pressure and a large proportion of these individuals are prescribed antihypertensive medications. Although large long-term clinical trials conducted in the last several decades have identified a number of...
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