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Article

Potential of polygenic risk scores for improving population estimates of women's breast cancer genetic risks.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Nov 2021

Wolfson Michael, Gribble Steve, Pashayan Nora, Easton Douglas F, Antoniou Antonis C, Lee Andrew, van Katwyk Sasha, Simard Jacques

Abstract excerpt

PURPOSE: Breast cancer risk has conventionally been assessed using family history (FH) and rare high/moderate penetrance pathogenic variants (PVs), notably in BRCA1/2, and more recently PALB2, CHEK2, and ATM. In addition to these PVs, it is now possible to use increasingly predictive polygenic risk scores (PRS) as well. The comparative population-level predictive capability of these three different indicators of...

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Identifiers

PMID: 34230637
DOI: 10.1038/s41436-021-01258-y
PMCID: PMC8553614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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