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Article

MIPUP: minimum perfect unmixed phylogenies for multi-sampled tumors via branchings and ILP.

Bioinformatics (Oxford, England) - 1 Mar 2019

Husić Edin, Li Xinyue, Hujdurović Ademir, Mehine Miika, Rizzi Romeo, Mäkinen Veli, Milanič Martin, Tomescu Alexandru I

Abstract excerpt

MOTIVATION: Discovering the evolution of a tumor may help identify driver mutations and provide a more comprehensive view on the history of the tumor. Recent studies have tackled this problem using multiple samples sequenced from a tumor, and due to clinical implications, this has attracted great interest. However, such samples usually mix several distinct tumor subclones, which confounds the discovery of the...

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PMID: 30101335
DOI: 10.1093/bioinformatics/bty683
PMCID: PMC6394401

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