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Article

The role of a functional variant of TYK2 in vasculitides and infections.

Clinical and experimental rheumatology - 1 Jan 2000

Ortiz-Fernández Lourdes, López-Mejias Raquel, Carmona Francisco D, Castaño-Nuñez Angel L, Lyons Paul A, Caruz Antonio, Gónzalez-Escribano Maria F, Smith Kenneth G C, González-Gay Miguel A, Martin Javier

Abstract excerpt

OBJECTIVES: The TYK2 gene encodes a tyrosin kinase which is involved in multiple immune functions. A functional variant of this gene has been identified to play a protective role in multiple autoimmune diseases. The goal of this study was to evaluate the involvement of this variant of TYK2 in vasculitides [giant cell arteritis (GCA), ANCA-associated vasculitis (AAV) and IgA vasculitis (IgAV)] and viral infections...

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PMID: 32167874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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