Article
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.
European journal of human genetics : EJHG - 1 Oct 2009
Ban Maria, Goris An, Lorentzen Aslaug R, Baker Amie, Mihalova Tania, Ingram Gillian, Booth David R, Heard Robert N, Stewart Graeme J, Bogaert Elke, Dubois Bénédicte, Harbo Hanne F, Celius Elisabeth G, Spurkland Anne, Strange Richard, Hawkins Clive, Robertson Neil P, Dudbridge Frank, Wason James, De Jager Philip L, Hafler David, Rioux John D, Ivinson Adrian J, McCauley Jacob L, Pericak-Vance Margaret, Oksenberg Jorge R, Hauser Stephen L, Sexton David, Haines Jonathan, Sawcer Stephen, Compston Alastair
Abstract excerpt
In a recent genome-wide association study (GWAS) based on 12,374 non-synonymous single nucleotide polymorphisms we identified a number of candidate multiple sclerosis susceptibility genes. Here, we describe the extended analysis of 17 of these loci undertaken using an additional 4234 patients, 2983 controls and 2053 trio families. In the final analysis combining all available data, we found that evidence for...
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