Article
Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility.
Brain : a journal of neurology - 1 Mar 2011
Couturier Nicolas, Bucciarelli Florence, Nurtdinov Ramil N, Debouverie Marc, Lebrun-Frenay Christine, Defer Gilles, Moreau Thibault, Confavreux Christian, Vukusic Sandra, Cournu-Rebeix Isabelle, Goertsches Robert H, Zettl Uwe K, Comabella Manuel, Montalban Xavier, Rieckmann Peter, Weber Frank, Müller-Myhsok Bertram, Edan Gilles, Fontaine Bertrand, Mars Lennart T, Saoudi Abdelhadi, Oksenberg Jorge R, Clanet Michel, Liblau Roland S, Brassat David
Abstract excerpt
The tyrosine kinase 2 variant rs34536443 has been established as a genetic risk factor for multiple sclerosis in a variety of populations. However, the functional effect of this variant on disease pathogenesis remains unclear. This study replicated the genetic association of tyrosine kinase 2 with multiple sclerosis in a cohort of 1366 French patients and 1802 controls. Furthermore, we assessed the functional...
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