Article
Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Journal of the American Heart Association - 6 Jul 2021
Takeshita Hikari, Yamamoto Koichi, Mogi Masaki, Wang Yu, Nozato Yoichi, Fujimoto Taku, Yokoyama Serina, Hongyo Kazuhiro, Nakagami Futoshi, Akasaka Hiroshi, Takami Yoichi, Takeya Yasushi, Sugimoto Ken, Horiuchi Masatsugu, Rakugi Hiromi
Abstract excerpt
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin-(1-7), respectively, is the primary process that counteracts activation of the canonical renin-angiotensin system (RAS). Although inhibition of canonical RAS could delay the progression of physiological aging, we recently reported that deletion of Mas had no impact on the aging process in mice....
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