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Article

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies.

Oncotarget - 20 May 2015

Burks Tyesha N, Marx Ruth, Powell Laura, Rucker Jasma, Bedja Djahida, Heacock Elisa, Smith Barbara J, Foster D Brian, Kass David, O'Rourke Brian, Walston Jeremy D, Abadir Peter M

Abstract excerpt

Although the effects of aging and inflammation on the health of the cardiac muscle are well documented, the combined effects of aging and chronic inflammation on cardiac muscle are largely unknown. The renin-angiotensin system (RAS) has been linked independently to both aging and inflammation, but is understudied in the context of their collective effect. Thus, we investigated localized cardiac angiotensin II...

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Identifiers

PMID: 26221650
DOI: 10.18632/oncotarget.3979
PMCID: PMC4494917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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