Article
Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene.
The Journal of biological chemistry - 22 Jan 1999
Periasamy M, Reed T D, Liu L H, Ji Y, Loukianov E, Paul R J, Nieman M L, Riddle T, Duffy J J, Doetschman T, Lorenz J N, Shull G E
Abstract excerpt
The sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene encodes both SERCA2a, the cardiac sarcoplasmic reticulum Ca2+ pump, and SERCA2b, which is expressed in all tissues. To gain a better understanding of the physiological functions of SERCA2, we used gene targeting to develop a mouse in which the promoter and 5' end of the gene were eliminated. Mating of heterozygous mutant mice yielded wild-type...
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