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Article

Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer's Disease Risk Reveal a Potential Role for SIGLEC14.

Genes - 30 Jun 2021

Shaw Benjamin C, Katsumata Yuriko, Simpson James F, Fardo David W, Estus Steven

Abstract excerpt

Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer's disease (AD), including TREM2 and CD33, frequently passing a stringent false-discovery rate. These genes either encode or signal through immunomodulatory tyrosine-phosphorylated inhibitory motifs (ITIMs) or activation motifs (ITAMs) and govern processes critical to AD pathology, such as inflammation and...

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Identifiers

PMID: 34208838
DOI: 10.3390/genes12071008
PMCID: PMC8303736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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