Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to l-asparaginase

8 Mar 2022

Abstract excerpt

Childhood T-cell acute lymphoblastic leukemia (T-ALL) still remains a therapeutic challenge due to relapses which are resistant to further treatment. L-asparaginase (ASNase) is a key therapy component in pediatric T-ALL and lower sensitivity of leukemia cells to this drug negatively influences overall treatment efficacy and outcome. PTEN protein deletion and/or activation of the PI3K/Akt signaling pathway leading...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Chronic Myeloid Leukemia Treatments
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35260738
DOI: 10.1038/s41598-022-08049-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to l-asparaginasePMID 35260738Read ↗

A clinically attainable dose of L‐asparaginase targets glutamine addiction in lymphoid cell linesSemantic proximity Read ↗

Asparagine: A Metabolite to Be Targeted in CancersSemantic proximity Read ↗

Update on the Use of L-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Metabolic Profile Of Leukemia Cells Influences Treatment Efficacy Of L‑AsparaginaseSemantic proximity Read ↗

SLC1A3 contributes to L‐asparaginase resistance in solid tumorsSemantic proximity Read ↗

Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginaseSemantic proximity Read ↗

A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancerSemantic proximity Read ↗

Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemiaSemantic proximity Read ↗

Targeting Asparagine Metabolism in Solid TumorsSemantic proximity Read ↗

The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

A Genome-Wide View of the In vitro Response to l -Asparaginase in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-AsparaginaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.