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Article

Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk.

Carcinogenesis - 1 Dec 2009

Chen Meng, Cassidy Adrian, Gu Jian, Delclos George L, Zhen Fan, Yang Hushan, Hildebrandt Michelle A T, Lin Jie, Ye Yuanqing, Chamberlain Robert M, Dinney Colin P, Wu Xifeng

Abstract excerpt

Genetic variations in phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway may affect critical cellular functions and increase an individual's cancer risk. We systematically evaluate 231 single-nucleotide polymorphisms (SNPs) in 19 genes in the PI3K-AKT-mTOR signaling pathway as predictors of bladder cancer risk. In individual SNP analysis, four SNPs in regulatory associated protein...

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Identifiers

PMID: 19875696
DOI: 10.1093/carcin/bgp258
PMCID: PMC2792319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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