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Article

PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.

Expert opinion on therapeutic targets - 1 Jun 2016

Hribal Marta Letizia, Mancuso Elettra, Spiga Rosangela, Mannino Gaia Chiara, Fiorentino Teresa Vanessa, Andreozzi Francesco, Sesti Giorgio

Abstract excerpt

INTRODUCTION: Pleckstrin homology domain leucine-rich repeat protein phosphatases (PHLPPs), originally identified as Akt kinase hydrophobic motif specific phosphatases, have subsequently been shown to regulate several molecules recurring within the insulin signaling pathway. This observation suggests that PHLPP phosphatases may have a clinically relevant role in the pathogenesis of insulin resistance-related...

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Identifiers

PMID: 26652182
DOI: 10.1517/14728222.2016.1130822

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